Weis Research Group


Front row from left: David Weis, Farai Rusinga, Mohammed Al-Naqshabandi
Back row: Walid Maaty, Michael Kim, Jayant Arora, Tyler Hageman, Jakki Stevens, Mihiri Weerasinghe.

Our lab uses the amide H/D exchange labeling technique combined with mass spectrometry to probe the conformation and dynamics of proteins and protein complexes.  We apply these techniques to better understand intrinsically disordered proteins and aggregation in therapeutic proteins.

Latest News

3 June 2015:  Mohammed presented a poster entitled "Millisecond HX-MS to detect residual helicity in a disordered protein using a denatured state reference" at the 63rd American Society for Mass Spectrometry conference in St. Louis.

3 June 2015:  David presented a talk entitled "Monte Carlo simulations of hydrogen exchange reveal surprising insights about the isotopic distribution" at the 63rd American Society for Mass Spectrometry conference in St. Louis.

5 May 2015:  Congratulations to Mike for earning Honors on his oral comprehensive exam!

16 April 2015:  Congratulations to Mohammed for earning the KU Graduate Research Competition award.

15 April 2015:  Jayant's paper on mAb reversible self-association has been published in mAbs.

14 April 2015:  Jayant presented a talk at the CASS Higher Order Structure conference in Boston.

1 April 2015:  Ted's paper on msec HX of ACTR has been published in the Emerging Investigators issue of JASMS.

5 December 2014:  Happy Birthday, Deuterium!  (Urey et al. Phys. Rev., 1932, 39, 164)

25 September 2014:  Ranajoy's review article "Hydrogen-deuterium exchange mass spectrometry as an emerging analytical tool for stabilization and formulation development of therapeutic monoclonal antibodies" has been accepted by the Journal of Pharmaceutical Sciences.

[All Lab News]

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